"Spermine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
| Descriptor ID |
D013096
|
| MeSH Number(s) |
D02.092.211.415.701.801.821 D02.092.782.802
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Spermine".
Below are MeSH descriptors whose meaning is more specific than "Spermine".
This graph shows the total number of publications written about "Spermine" by people in this website by year, and whether "Spermine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 3 | 2 | 5 |
| 2007 | 1 | 2 | 3 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 2 | 3 |
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Below are the most recent publications written about "Spermine" by people in Profiles.
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Plasma Biomarkers and Fractional Exhaled Nitric Oxide in the Diagnosis of Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2023 01 01; 76(1):59-65.
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Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Med Sci (Basel). 2022 08 30; 10(3).
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Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus. Ann Rheum Dis. 2022 Dec; 81(12):1712-1721.
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Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. 2020 05; 39(22):4465-4474.
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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9.
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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677.
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Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism. Mol Cancer Ther. 2013 Oct; 12(10):2088-99.
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Design of serum compatible tetrary complexes for gene delivery. Macromol Biosci. 2012 May; 12(5):637-46.
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Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 2012 Feb; 42(2-3):529-38.
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Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer. 2010 Oct 14; 10:555.