Inositol 1,4,5-Trisphosphate
"Inositol 1,4,5-Trisphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
| Descriptor ID |
D015544
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| MeSH Number(s) |
D02.033.800.519.400.350 D09.853.519.400.350 D09.894.480.350
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Triphosphate
- Myoinositol 1,4,5-Triphosphate
- 1,4,5-InsP3
- 1,4,5-IP3
- Myo-Inositol 1,4,5-Trisphosphate
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate".
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate" by people in Profiles.
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Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G297-305.
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A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor. J Biol Chem. 2004 Aug 27; 279(35):36601-7.
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Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors. J Biol Chem. 1998 Aug 28; 273(35):22753-60.
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Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature. 1995 Oct 05; 377(6548):438-41.
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12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7.
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Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes. Cell Signal. 1993 Sep; 5(5):593-603.
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Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells. Am J Physiol. 1993 Jan; 264(1 Pt 2):H86-96.
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15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate. Blood. 1992 Dec 01; 80(11):2765-73.
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Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties. J Biol Chem. 1991 May 25; 266(15):9771-7.
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Angiotensin II surface receptor coupling to inositol trisphosphate formation in vascular smooth muscle cells. J Biol Chem. 1990 Jan 05; 265(1):195-200.