PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet. 2016 Dec; 12(12):e1006518.

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subject areas

Apoptosis
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Transformation, Neoplastic
eIF-2 Kinase
Endoplasmic Reticulum
Gene Dosage
Haploinsufficiency
Humans
Melanoma
Mutation
Proto-Oncogene Proteins B-raf
Signal Transduction
Small Molecule Libraries
Tumor Suppressor Proteins
Unfolded Protein Response

authors with profiles

Olga Susanne Chajewski
Dariusz Maciej Pytel