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    • Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.

View in: PubMed

subject areas
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Aorta
  • Apolipoproteins E
  • Calgranulin A
  • Cathepsin K
  • Cathepsins
  • Cell Membrane
  • Cells, Cultured
  • Cholesterol
  • E-Box Elements
  • Endosomes
  • Enzyme Induction
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Macrophages
  • Matrix Metalloproteinase 14
  • Matrix Metalloproteinase 8
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microphthalmia-Associated Transcription Factor
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Promoter Regions, Genetic
  • Proteins
  • rab GTP-Binding Proteins
  • Receptor Activator of Nuclear Factor-kappa B
  • S100 Proteins
  • Signal Transduction
  • Time Factors
  • Toll-Like Receptor 3
  • Toll-Like Receptor 4

authors with profiles
  • Michael C Ostrowski
  • Sudarshana Sharma