Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells.

Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells. Cancer Chemother Pharmacol. 2008 Aug; 62(3):407-16.

View in: PubMed

subject areas

Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Astrocytes
Blotting, Western
Cell Culture Techniques
Cell Cycle
Cell Line, Tumor
Cell Survival
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p27
Cytochromes c
Cytosol
DNA Fragmentation
Down-Regulation
Glioblastoma
Humans
In Situ Nick-End Labeling
Interferon-gamma
Mitochondria
PTEN Phosphohydrolase
Recombinant Proteins
Tretinoin
Up-Regulation

authors with profiles

Swapan KUMAR Ray