"Dysbindin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.
| Descriptor ID |
D000074765
|
| MeSH Number(s) |
D12.776.210.500.410.250 D12.776.220.362.125 D12.776.543.268.250 D12.776.543.990.447 D12.776.631.262
|
| Concept/Terms |
Dysbindin- Dysbindin
- Hermansky-Pudlak Syndrome 7 Protein
- Hermansky Pudlak Syndrome 7 Protein
- Dysbindin-1
- Dysbindin 1
- Dystrobrevin Binding Protein 1
- DTNBP1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Dysbindin".
Below are MeSH descriptors whose meaning is more specific than "Dysbindin".
This graph shows the total number of publications written about "Dysbindin" by people in this website by year, and whether "Dysbindin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dysbindin" by people in Profiles.
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Loss of dysbindin-1 affects GABAergic transmission in the PFC. Psychopharmacology (Berl). 2019 Nov; 236(11):3291-3300.
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Effects of fingolimod administration in a genetic model of cognitive deficits. J Neurosci Res. 2017 05; 95(5):1174-1181.
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Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning. Hippocampus. 2014 Feb; 24(2):204-13.
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Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice. Schizophr Res. 2013 May; 146(1-3):254-63.
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Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance. Biol Psychiatry. 2011 Jan 01; 69(1):28-34.
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Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology. 2009 Nov; 34(12):2601-8.