"Synapsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
| Descriptor ID |
D016704
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| MeSH Number(s) |
D12.776.631.750 D12.776.744.840
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapsins".
Below are MeSH descriptors whose meaning is more specific than "Synapsins".
This graph shows the total number of publications written about "Synapsins" by people in this website by year, and whether "Synapsins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synapsins" by people in Profiles.
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Gene vector 'magic bullet': targeted expression in the central nervous system after peripheral delivery using the synapsin promoter. Expert Opin Ther Targets. 2016 10; 20(10):1153-4.
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Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biol Psychiatry. 2016 08 01; 80(3):207-15.
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A single brain-derived neurotrophic factor infusion into the dorsomedial prefrontal cortex attenuates cocaine self-administration-induced phosphorylation of synapsin in the nucleus accumbens during early withdrawal. Int J Neuropsychopharmacol. 2014 Dec 05; 18(1).
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Relapse to cocaine-seeking after abstinence is regulated by cAMP-dependent protein kinase A in the prefrontal cortex. Addict Biol. 2014 Jan; 19(1):77-86.
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Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 08; 24(36):7859-68.
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Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis. J Neurosci. 2002 Jul 15; 22(14):5900-9.