A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Descriptor ID	D013254
MeSH Number(s)	D08.244.453.487.500 D08.244.453.915.748 D08.811.682.690.708.170.444.500 D08.811.682.690.708.170.915.748 D12.776.422.220.453.487.500 D12.776.422.220.453.915.748
Concept/Terms	Steroid 17-alpha-Hydroxylase Steroid 17-alpha-Hydroxylase 17-alpha-Hydroxylase, Steroid Steroid 17 alpha-Hydroxylase 17 alpha-Hydroxylase, Steroid Steroid 17 alpha Hydroxylase Steroid-17-Hydroxylase Steroid 17 Hydroxylase Steroid 17-Hydroxylase 17-Hydroxylase, Steroid Steroid 17-Monooxygenase 17-Monooxygenase, Steroid Steroid 17 Monooxygenase 17,20-Desmolase 17,20 Desmolase 17,20-Lyase 17,20 Lyase Cytochrome P450(17 alpha) Steroid 17 alpha-Monooxygenase 17 alpha-Monooxygenase, Steroid Steroid 17 alpha Monooxygenase alpha-Monooxygenase, Steroid 17 CYP17 17 alpha-Hydroxylase 17 alpha Hydroxylase P450(c17) Cytochrome P-450(17-alpha) 17 alpha-Hydroxylase Cytochrome P-450 17 alpha Hydroxylase Cytochrome P 450 Cytochrome P-450(17 alpha) 17 alpha-Hydroxyprogesterone Aldolase 17 alpha-Hydroxyprogesterone Aldolase 17 alpha Hydroxyprogesterone Aldolase Aldolase, 17 alpha-Hydroxyprogesterone alpha-Hydroxyprogesterone Aldolase, 17 Hydroxyprogesterone Aldolase Aldolase, Hydroxyprogesterone

Below are MeSH descriptors whose meaning is more general than "Steroid 17-alpha-Hydroxylase".

Below are MeSH descriptors whose meaning is related to "Steroid 17-alpha-Hydroxylase".

Below are MeSH descriptors whose meaning is more specific than "Steroid 17-alpha-Hydroxylase".