12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
| Descriptor ID |
D019377
|
| MeSH Number(s) |
D10.251.355.255.100.300.425 D10.251.355.310.166.550.425
|
| Concept/Terms |
12-S-HETE- 12-S-HETE
- 12-S-Hydroxyeicosatetraenoic Acid
- 12 S Hydroxyeicosatetraenoic Acid
- Acid, 12-S-Hydroxyeicosatetraenoic
|
Below are MeSH descriptors whose meaning is more general than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
Below are MeSH descriptors whose meaning is more specific than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
This graph shows the total number of publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in this website by year, and whether "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in Profiles.
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12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci. 2003 Dec 10; 23(36):11427-35.
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12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18.
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12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7.
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12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51.