Inhibitor of Apoptosis Proteins

"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Descriptor ID	D051034
MeSH Number(s)	D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
Concept/Terms	Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Apoptosis Proteins Inhibitor Inhibitor-Of-Apoptosis Protein Inhibitor Of Apoptosis Protein Baculoviral Inhibitor Of Apoptosis Repeat Proteins IAP Repeat Containing Proteins IAP Protein (Apoptosis) Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat Containing 2 Protein Cellular Inhibitor of Apoptosis 1 Protein IAP2 Protein c-IAP1 Protein cIAP1 Protein Inhibitor of Apoptosis 2 Protein BIRC2 Protein Baculoviral IAP Repeat Containing Protein 2

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Apoptosis Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".

Inhibitor of Apoptosis Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
X-Linked Inhibitor of Apoptosis Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.

Bar chart showing 24 publications over 12 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	2	2
2006	0	1	1
2007	1	3	4
2008	0	2	2
2009	0	2	2
2010	0	1	1
2011	0	3	3
2012	2	0	2
2013	0	2	2
2014	1	1	2
2015	0	1	1
2016	2	0	2

Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.

Chakrabarti M, Klionsky DJ, Ray SK. miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells. PLoS One. 2016; 11(7):e0158537.

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Jenkins R, Bandera YP, Daniele MA, Ledford LL, Tietje A, Kelso AA, Sehorn MG, Wei Y, Chakrabarti M, Ray SK, Foulger SH. Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells. Biomater Sci. 2016 Apr; 4(4):614-26.

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Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10.

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Wang J, Lu Z, Yeung BZ, Wientjes MG, Cole DJ, Au JL. Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors. J Control Release. 2014 Mar 28; 178:79-85.

View in: PubMed
Paschall AV, Zimmerman MA, Torres CM, Yang D, Chen MR, Li X, Bieberich E, Bai A, Bielawski J, Bielawska A, Liu K. Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression. BMC Cancer. 2014 Jan 15; 14:24.

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Hua Y, White-Gilbertson S, Kellner J, Rachidi S, Usmani SZ, Chiosis G, Depinho R, Li Z, Liu B. Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res. 2013 Nov 15; 19(22):6242-51.

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Shintaku J, Guttridge DC. Reining in nuclear factor-kappaB in skeletal muscle disorders. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3):251-7.

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Khan S, Jutzy JM, Valenzuela MM, Turay D, Aspe JR, Ashok A, Mirshahidi S, Mercola D, Lilly MB, Wall NR. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS One. 2012; 7(10):e46737.

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Hossain MM, Banik NL, Ray SK. Survivin knockdown increased anti-cancer effects of (-)-epigallocatechin-3-gallate in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Exp Cell Res. 2012 Aug 01; 318(13):1597-610.

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Mayes PA, Dolloff NG, Daniel CJ, Liu JJ, Hart LS, Kuribayashi K, Allen JE, Jee DI, Dorsey JF, Liu YY, Dicker DT, Brown JM, Furth EE, Klein PS, Sears RC, El-Deiry WS. Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3ß and CDK1. Cancer Res. 2011 Aug 01; 71(15):5265-75.

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