JNK Mitogen-Activated Protein Kinases

"JNK Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.

Descriptor ID	D048031
MeSH Number(s)	D08.811.913.696.620.682.700.567.374 D12.644.360.450.340 D12.776.476.450.340
Concept/Terms	JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases JNK Mitogen Activated Protein Kinases jun-NH2-Terminal Kinase jun NH2 Terminal Kinase jun-NH2-Terminal Kinases jun NH2 Terminal Kinases c-jun Amino-Terminal Kinase Amino-Terminal Kinase, c-jun c jun Amino Terminal Kinase c-jun N-Terminal Kinase N-Terminal Kinase, c-jun c jun N Terminal Kinase

Below are MeSH descriptors whose meaning is more general than "JNK Mitogen-Activated Protein Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
JNK Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.374]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
JNK Mitogen-Activated Protein Kinases [D12.644.360.450.340]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
JNK Mitogen-Activated Protein Kinases [D12.776.476.450.340]

Below are MeSH descriptors whose meaning is related to "JNK Mitogen-Activated Protein Kinases".

Below are MeSH descriptors whose meaning is more specific than "JNK Mitogen-Activated Protein Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "JNK Mitogen-Activated Protein Kinases" by people in this website by year, and whether "JNK Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.

Bar chart showing 98 publications over 25 distinct years, with a maximum of 13 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	3	3
1996	1	3	4
1997	0	1	1
1998	2	2	4
1999	1	5	6
2000	2	3	5
2001	0	6	6
2002	0	2	2
2003	1	6	7
2004	2	5	7
2005	1	4	5
2006	4	9	13
2007	1	0	1
2008	1	3	4
2009	4	5	9
2010	2	4	6
2011	1	0	1
2012	0	2	2
2013	1	2	3
2014	0	3	3
2015	2	0	2
2016	0	1	1
2017	0	1	1
2019	1	0	1

Below are the most recent publications written about "JNK Mitogen-Activated Protein Kinases" by people in Profiles.

Heslop KA, Rovini A, Hunt EG, Fang D, Morris ME, Christie CF, Gooz MB, DeHart DN, Dang Y, Lemasters JJ, Maldonado EN. JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells. Biochem Pharmacol. 2020 01; 171:113728.

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Wang J, Sun Z, Gou W, Adams DB, Cui W, Morgan KA, Strange C, Wang H. a-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction. Diabetes. 2017 04; 66(4):970-980.

View in: PubMed
Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H. Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):636-46.

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Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicol Sci. 2016 Mar; 150(1):204-15.

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Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. J Biol Chem. 2015 May 22; 290(21):13157-67.

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Sundaram K, Sambandam Y, Balasubramanian S, Pillai B, Voelkel-Johnson C, Ries WL, Reddy SV. STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells. Bone. 2015 Feb; 71:137-44.

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Sundaram K, Sambandam Y, Tsuruga E, Wagner CL, Reddy SV. 1a,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells. Horm Cancer. 2014 Apr; 5(2):90-7.

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Liu Q, Wang J, Liang Q, Wang D, Luo Y, Li J, Janicki JS, Fan D. Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation. Exp Biol Med (Maywood). 2014 Mar; 239(3):376-84.

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Valerio MS, Herbert BA, Griffin AC, Wan Z, Hill EG, Kirkwood KL. MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation. Bone. 2014 Mar; 60:16-25.

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Li QQ, Lee RX, Liang H, Wang G, Li JM, Zhong Y, Reed E. ß-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK. Int J Oncol. 2013 Sep; 43(3):721-8.

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