Mitogen-Activated Protein Kinase 8
"Mitogen-Activated Protein Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
| Descriptor ID |
D048055
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.374.500 D12.644.360.450.340.500 D12.776.476.450.340.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 8- Mitogen-Activated Protein Kinase 8
- Mitogen Activated Protein Kinase 8
- c-jun Kinase-1
- c jun Kinase 1
- SAP Kinase-1
- SAP Kinase 1
- Stress-Activated Protein Kinase gamma
- Stress Activated Protein Kinase gamma
- c-jun N-Terminal Kinase 1
- c jun N Terminal Kinase 1
- MAPK8 Mitogen-Activated Protein Kinase
- MAPK8 Mitogen Activated Protein Kinase
- JNK1 Kinase
- SAPK1 Mitogen-Activated Protein Kinase
- SAPK1 Mitogen Activated Protein Kinase
- Stress-Activated Protein Kinase 1
- Stress Activated Protein Kinase 1
- Stress-Activated Protein Kinase JNK1
- Stress Activated Protein Kinase JNK1
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 8".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 8" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 8" by people in Profiles.
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Inhibition of NFAM1 suppresses phospho-SAPK/JNK signaling during osteoclast differentiation and bone resorption. J Cell Biochem. 2021 10; 122(10):1534-1543.
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The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases. BMC Cancer. 2019 Aug 16; 19(1):812.
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JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1. Cell Death Dis. 2014 Jul 31; 5:e1358.
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Mitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion. Mol Cell Biol. 2012 Jul; 32(14):2880-93.
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A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. J Virol. 2012 Jan; 86(1):172-84.
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Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science. 2011 Apr 15; 332(6027):358-61.
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Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death. Liver Transpl. 2010 Nov; 16(11):1267-77.
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Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. Cancer. 2010 Jan 01; 116(1):164-76.
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Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells. Cancer. 2007 Sep 01; 110(5):1083-95.
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Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 2006 Dec 25; 203(13):2895-906.