Thioredoxins

"Thioredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.

Descriptor ID	D013879
MeSH Number(s)	D12.776.915
Concept/Terms	Thioredoxins Thioredoxins Thioredoxin Thioredoxin 2 Thioredoxin 2 Thioredoxin-2 Thioredoxin 1 Thioredoxin 1 Thioredoxin-1

Below are MeSH descriptors whose meaning is more general than "Thioredoxins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Thioredoxins [D12.776.915]

Below are MeSH descriptors whose meaning is related to "Thioredoxins".

Below are MeSH descriptors whose meaning is more specific than "Thioredoxins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thioredoxins" by people in this website by year, and whether "Thioredoxins" was a major or minor topic of these publications.

Bar chart showing 14 publications over 9 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	0	1
2007	0	1	1
2009	0	3	3
2010	2	0	2
2013	1	0	1
2014	2	0	2
2015	1	0	1
2019	2	0	2

Below are the most recent publications written about "Thioredoxins" by people in Profiles.

Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ. Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. J Clin Invest. 2019 05 02; 129(7):2760-2774.

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Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S. Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. J Biol Chem. 2019 06 07; 294(23):9198-9212.

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Vance TM, Azabdaftari G, Pop EA, Lee SG, Su LJ, Fontham ET, Bensen JT, Steck SE, Arab L, Mohler JL, Chen MH, Koo SI, Chun OK. Intake of dietary antioxidants is inversely associated with biomarkers of oxidative stress among men with prostate cancer. Br J Nutr. 2016 Jan 14; 115(1):68-74.

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Abdelsaid MA, Matragoon S, Ergul A, El-Remessy AB. Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy. PLoS One. 2014; 9(10):e110388.

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Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC. Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 2015 Apr; 51(2):766-78.

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An N, Janech MG, Bland AM, Lazarchick J, Arthur JM, Kang Y. Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution. Exp Hematol. 2013 Nov; 41(11):944-56.

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Lee HW, Hitchcock TM, Park SH, Mi R, Kraft JD, Luo J, Cao W. Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress. Free Radic Biol Med. 2010 Sep 01; 49(5):872-80.

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Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Res. 2010 Feb 01; 70(3):1120-9.

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Moussa O, Turner DP, Feldman RJ, Sementchenko VI, McCarragher BD, Desouki MM, Fraig M, Watson DK. PDEF is a negative regulator of colon cancer cell growth and migration. J Cell Biochem. 2009 Dec 15; 108(6):1389-98.

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Neumann CA, Cao J, Manevich Y. Peroxiredoxin 1 and its role in cell signaling. Cell Cycle. 2009 Dec 15; 8(24):4072-8.

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