"Huntingtin Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.
| Descriptor ID |
D000071058
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| MeSH Number(s) |
D12.776.441
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Huntingtin Protein".
Below are MeSH descriptors whose meaning is more specific than "Huntingtin Protein".
This graph shows the total number of publications written about "Huntingtin Protein" by people in this website by year, and whether "Huntingtin Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Huntingtin Protein" by people in Profiles.
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Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA. PLoS One. 2020; 15(7):e0233583.
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Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes. Amino Acids. 2017 03; 49(3):501-515.
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Writer's cramp: a potential early feature of Huntington's disease. Mov Disord. 2010 Apr 30; 25(6):785-6.
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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug 01; 16(15):1862-71.
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Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin. J Biol Chem. 2007 Mar 30; 282(13):10096-10103.