Parathyroid Hormone-Related Protein

"Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.

Descriptor ID	D044162
MeSH Number(s)	D06.472.699.591 D12.644.276.908 D12.644.548.588 D12.776.467.890 D23.529.890
Concept/Terms	Parathyroid Hormone-Related Protein Parathyroid Hormone-Related Protein Hormone-Related Protein, Parathyroid Parathyroid Hormone Related Protein Parathyroid Hormone-Like Protein Parathyroid Hormone Like Protein Parathyroid Hormone-Related Peptide Parathyroid Hormone Related Peptide PTHrP Tumor Hypercalcemic Factor Hypercalcemic Factor, Tumor Hypercalcemic Hormone of Malignancy PTH Like Tumor Factor PTH-Like Protein PTH Like Protein Parathyroid Hormone Like Tumor Factor PTH-Related Peptide PTH Related Peptide

Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone-Related Protein".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Parathyroid Hormone-Related Protein [D06.472.699.591]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Parathyroid Hormone-Related Protein [D12.644.276.908]
Peptide Hormones [D12.644.548]
Parathyroid Hormone-Related Protein [D12.644.548.588]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Parathyroid Hormone-Related Protein [D12.776.467.890]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Parathyroid Hormone-Related Protein [D23.529.890]

Below are MeSH descriptors whose meaning is related to "Parathyroid Hormone-Related Protein".

Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone-Related Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website by year, and whether "Parathyroid Hormone-Related Protein" was a major or minor topic of these publications.

Bar chart showing 13 publications over 10 distinct years, with a maximum of 2 publications in 2005 and 2010 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2002	0	1	1
2003	1	0	1
2004	1	0	1
2005	2	0	2
2006	0	1	1
2007	1	0	1
2009	0	1	1
2010	2	0	2
2011	1	1	2

Below are the most recent publications written about "Parathyroid Hormone-Related Protein" by people in Profiles.

Horwitz MJ, Tedesco MB, Sereika SM, Prebehala L, Gundberg CM, Hollis BW, Bisello A, Garcia-Ocaña A, Carneiro RM, Stewart AF. A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover. J Bone Miner Res. 2011 Sep; 26(9):2287-97.

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Tarnawa E, Sullivan S, Underwood P, Richardson M, Spruill L. Severe hypercalcemia associated with uterine leiomyoma in pregnancy. Obstet Gynecol. 2011 Feb; 117(2 Pt 2):473-476.

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Toribio RE, Brown HA, Novince CM, Marlow B, Hernon K, Lanigan LG, Hildreth BE, Werbeck JL, Shu ST, Lorch G, Carlton M, Foley J, Boyaka P, McCauley LK, Rosol TJ. The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010 Jun; 24(6):1947-57.

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Horwitz MJ, Tedesco MB, Garcia-Ocaña A, Sereika SM, Prebehala L, Bisello A, Hollis BW, Gundberg CM, Stewart AF. Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose. J Clin Endocrinol Metab. 2010 Mar; 95(3):1279-87.

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Cackowski FC, Anderson JL, Patrene KD, Choksi RJ, Shapiro SD, Windle JJ, Blair HC, Roodman GD. Osteoclasts are important for bone angiogenesis. Blood. 2010 Jan 07; 115(1):140-9.

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Nadella MV, Dirksen WP, Nadella KS, Shu S, Cheng AS, Morgenstern JA, Richard V, Fernandez SA, Huang TH, Guttridge D, Rosol TJ. Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62.

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Fisher JL, Thomas-Mudge RJ, Elliott J, Hards DK, Sims NA, Slavin J, Martin TJ, Gillespie MT. Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Cancer Res. 2006 Apr 01; 66(7):3620-8.

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Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocaña A, Bisello A, Hollis BW, Gundberg C, Stewart AF. Safety and tolerability of subcutaneous PTHrP(1-36) in healthy human volunteers: a dose escalation study. Osteoporos Int. 2006 Feb; 17(2):225-30.

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Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. J Bone Miner Res. 2005 Oct; 20(10):1792-803.

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Chaudhary UB, Milling DL, Bissada NK. Transitional cell carcinoma of the bladder producing parathyroid hormone-related protein (PTHrP). Can J Urol. 2004 Feb; 11(1):2136-8.

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