GTP-Binding Protein alpha Subunits, Gi-Go
"GTP-Binding Protein alpha Subunits, Gi-Go" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
| Descriptor ID |
D019206
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| MeSH Number(s) |
D08.811.277.040.330.300.200.100.200 D12.644.360.360.100.200 D12.776.157.325.332.100.200 D12.776.476.375.100.200 D12.776.543.325.100.200
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| Concept/Terms |
GTP-Binding Protein alpha Subunits, Gi-Go- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP Binding Protein alpha Subunits, Gi Go
- G-Protein, Gi-Go Subunits
- G Protein, Gi Go Subunits
- Gi-Go Subunits G-Protein
- Subunits G-Protein, Gi-Go
- Gi-Go G-Proteins
- G-Proteins, Gi-Go
- Gi Go G Proteins
- G-Protein, Gi-Go alpha Family
- G Protein, Gi Go alpha Family
GTP-Binding Protein alpha Subunit, Go1- GTP-Binding Protein alpha Subunit, Go1
- GTP Binding Protein alpha Subunit, Go1
- G-Protein, Go1 Subunit
- G Protein, Go1 Subunit
- Go1 Subunit G-Protein
- Subunit G-Protein, Go1
- G(o1)alpha
GTP-Binding Protein alpha Subunit, Go- GTP-Binding Protein alpha Subunit, Go
- GTP Binding Protein alpha Subunit, Go
- Guanine Nucleotide-Binding Protein Go
- Guanine Nucleotide Binding Protein Go
- Go Alpha Subunit
- Alpha Subunit, Go
- Subunit, Go Alpha
- G-Protein, Inhibitory Go
- G Protein, Inhibitory Go
- Go G-Protein, Inhibitory
- Inhibitory Go G-Protein
- G-Protein, Go Subunit
- G Protein, Go Subunit
- Go Subunit G-Protein
- Subunit G-Protein, Go
- G Protein Go
- Go, G Protein
- G(o) Protein
GTP-Binding Protein alpha Subunit, Gi- GTP-Binding Protein alpha Subunit, Gi
- GTP Binding Protein alpha Subunit, Gi
- Gi, Inhibitory G-Protein
- Gi, Inhibitory G Protein
- Inhibitory G-Protein Gi
- G-Protein, Inhibitory Gi
- G Protein, Inhibitory Gi
- Gi G-Protein, Inhibitory
- Inhibitory Gi G-Protein
- G-Protein, Gi Subunit
- G Protein, Gi Subunit
- Gi Subunit G-Protein
- Subunit G-Protein, Gi
- Gi alpha Subunit
- Subunit, Gi alpha
- alpha Subunit, Gi
- Ni Protein
- Gi-Alpha Protein
- Gi Alpha Protein
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Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, Gi-Go".
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, Gi-Go".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, Gi-Go" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, Gi-Go" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 1 | 3 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 3 | 3 | 6 |
| 2010 | 2 | 0 | 2 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, Gi-Go" by people in Profiles.
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Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403.
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Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gai G-Protein Regulatory Motif Complex. Mol Pharmacol. 2015 Aug; 88(2):231-7.
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Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells. Methods Mol Biol. 2015; 1278:457-65.
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Development of inhibitors of heterotrimeric Gai subunits. Bioorg Med Chem. 2014 Jul 01; 22(13):3423-34.
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Normal autophagic activity in macrophages from mice lacking Gai3, AGS3, or RGS19. PLoS One. 2013; 8(11):e81886.
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Group II activators of G-protein signaling: monitoring the interaction of Ga with the G-protein regulatory motif in the intact cell. Methods Enzymol. 2013; 522:153-67.
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Assembly and function of the regulator of G protein signaling 14 (RGS14)?H-Ras signaling complex in live cells are regulated by Gai1 and Gai-linked G protein-coupled receptors. J Biol Chem. 2013 Feb 01; 288(5):3620-31.
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Regulation of the G-protein regulatory-Gai signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem. 2013 Feb 01; 288(5):3003-15.
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G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14?Gai1 complex in live cells. J Biol Chem. 2011 Nov 04; 286(44):38659-38669.
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Heterotrimeric Ga(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011 Mar; 1813(3):466-72.