Anaphase-Promoting Complex-Cyclosome
"Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
| Descriptor ID |
D064173
|
| MeSH Number(s) |
D08.811.464.938.750.092 D12.776.167.024
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Anaphase-Promoting Complex-Cyclosome".
Below are MeSH descriptors whose meaning is more specific than "Anaphase-Promoting Complex-Cyclosome".
- Anaphase-Promoting Complex-Cyclosome
- Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cdc20 Proteins
- Cdh1 Proteins
This graph shows the total number of publications written about "Anaphase-Promoting Complex-Cyclosome" by people in this website by year, and whether "Anaphase-Promoting Complex-Cyclosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
-
Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9423-9432.
-
Biggs JR, Peterson LF, Zhang Y, Kraft AS, Zhang DE. AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol. 2006 Oct; 26(20):7420-9.