"Zinc Finger Protein GLI1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS. Two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the CENTRAL NERVOUS SYSTEM; and the GASTROINTESTINAL TRACT. They also regulate SONIC HEDGEHOG PROTEIN signaling and cell proliferation.
| Descriptor ID |
D000071676
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| MeSH Number(s) |
D12.776.260.755.850 D12.776.624.664.700.989 D12.776.930.900.700
|
| Concept/Terms |
Zinc Finger Protein GLI1- Zinc Finger Protein GLI1
- Oncogene GLI Protein
- GLI Protein, Oncogene
- Glioma-Associated Oncogene Protein
- Glioma Associated Oncogene Protein
- Oncogene Protein, Glioma-Associated
- Gli Protein
- Gli1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein GLI1".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein GLI1".
This graph shows the total number of publications written about "Zinc Finger Protein GLI1" by people in this website by year, and whether "Zinc Finger Protein GLI1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Zinc Finger Protein GLI1" by people in Profiles.
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Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell. 2022 10 06; 29(10):1459-1474.e9.
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Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse. Sci Adv. 2022 07 22; 8(29):eabj9138.
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Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis. Nat Commun. 2019 07 10; 10(1):3028.
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A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 02 15; 25(4):1379-1388.
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A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer. Breast Cancer Res Treat. 2018 Jun; 169(3):457-467.
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Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016 Dec 02; 291(49):25749-25760.
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Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells. Oncogene. 2016 Jan 07; 35(1):116-24.
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The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. J Biol Chem. 2014 Dec 19; 289(51):35494-502.
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Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer Res. 2014 Sep 01; 74(17):4811-21.
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Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res. 2011 Jul 01; 71(13):4454-63.