Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
"Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
| Descriptor ID |
D000074884
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| MeSH Number(s) |
D08.811.277.656.262.500.126.775 D08.811.277.656.300.200.126.775 D08.811.464.938.750.233
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein".
This graph shows the total number of publications written about "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein" by people in this website by year, and whether "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein" by people in Profiles.
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MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-?B Signaling and Inflammatory Responsiveness. Front Immunol. 2021; 12:749794.
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The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-?B signalling. Nat Commun. 2015 Nov 03; 6:8777.