Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
| Descriptor ID |
D055504
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| MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
This graph shows the total number of publications written about "Insulin Receptor Substrate Proteins" by people in this website by year, and whether "Insulin Receptor Substrate Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles.
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Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. Sci Rep. 2020 05 05; 10(1):7605.
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Oncotarget. 2016 Apr 12; 7(15):20152-65.
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AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity. Biochem Biophys Res Commun. 2013 Apr 19; 433(4):567-72.
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Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010 Feb; 16(2):219-23.
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O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics. 2009 Dec; 8(12):2733-45.
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Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis. Endocrinology. 2006 Jul; 147(7):3547-54.
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Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics. 2006 Feb; 5(2):313-23.
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VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. Kidney Int. 2005 Oct; 68(4):1648-59.
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PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38.
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Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8.