Crk-Associated Substrate Protein
"Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
| Descriptor ID |
D050719
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| MeSH Number(s) |
D12.644.360.024.282 D12.776.157.057.016 D12.776.476.024.316 D12.776.744.425
|
| Concept/Terms |
Crk-Associated Substrate Protein- Crk-Associated Substrate Protein
- Crk Associated Substrate Protein
- Substrate Protein, Crk-Associated
- p130 Cas Protein
- Cas Protein, p130
- BCAR1 Protein
- p130 Crk-Associated Substrate
- Crk-Associated Substrate, p130
- Substrate, p130 Crk-Associated
- p130 Crk Associated Substrate
- p130Cas Protein
- Breast Cancer Anti-Estrogen Resistance 1 Protein
- Breast Cancer Anti Estrogen Resistance 1 Protein
- Crk-Associated Substrate
- Crk Associated Substrate
- CKRAS Protein
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Below are MeSH descriptors whose meaning is more general than "Crk-Associated Substrate Protein".
Below are MeSH descriptors whose meaning is more specific than "Crk-Associated Substrate Protein".
This graph shows the total number of publications written about "Crk-Associated Substrate Protein" by people in this website by year, and whether "Crk-Associated Substrate Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Crk-Associated Substrate Protein" by people in Profiles.
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Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. J Cell Sci. 2017 01 01; 130(1):152-163.
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A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium. J Cell Biochem. 2015 Dec; 116(12):2793-803.
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Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb; 122(2):674-92.
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Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst. 2011 Nov 02; 103(21):1596-612.
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Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem. 2005 Dec 01; 96(5):906-13.