Homer Scaffolding Proteins
"Homer Scaffolding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
| Descriptor ID |
D000072233
|
| MeSH Number(s) |
D12.776.476.024.381
|
| Concept/Terms |
Homer Scaffolding Proteins- Homer Scaffolding Proteins
- Proteins, Homer Scaffolding
- Scaffolding Proteins, Homer
- Homer Proteins
- Proteins, Homer
Homer 1C- Homer 1C
- Homer 1C Proteins
- Proteins, Homer 1C
Homer 3- Homer 3
- Homer 3 Proteins
- Proteins, Homer 3
Homer 2- Homer 2
- Homer 2 Proteins
- Proteins, Homer 2
Homer 1a- Homer 1a
- Homer 1 Proteins
- Proteins, Homer 1
|
Below are MeSH descriptors whose meaning is more general than "Homer Scaffolding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Homer Scaffolding Proteins".
This graph shows the total number of publications written about "Homer Scaffolding Proteins" by people in this website by year, and whether "Homer Scaffolding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Homer Scaffolding Proteins" by people in Profiles.
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Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse. 2016 Jan; 70(1):33-9.
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Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol. 2013 Jan; 18(1):40-9.
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Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci. 2010 Jun 09; 30(23):7984-92.
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Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. Synapse. 2009 Jan; 63(1):42-53.
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Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol Cell Biol. 2008 Apr; 28(8):2637-47.
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Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol. 2006 Jun; 16(3):251-7.
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Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr; 31(4):768-77.
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Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure. Alcohol Clin Exp Res. 2006 Feb; 30(2):368-76.
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Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci. 2005 Dec 14; 25(50):11586-94.
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Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci. 2005 Jul 27; 25(30):7054-61.