"Dishevelled Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
| Descriptor ID |
D000072261
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| MeSH Number(s) |
D12.644.360.024.288 D12.776.157.057.028 D12.776.476.024.330
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dishevelled Proteins".
Below are MeSH descriptors whose meaning is more specific than "Dishevelled Proteins".
This graph shows the total number of publications written about "Dishevelled Proteins" by people in this website by year, and whether "Dishevelled Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dishevelled Proteins" by people in Profiles.
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Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 2003 Jun 16; 22(12):3084-94.