"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
| Descriptor ID |
D051380
|
| MeSH Number(s) |
D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377
|
| Concept/Terms |
GRB2 Adaptor Protein- GRB2 Adaptor Protein
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
|
Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".
This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.
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Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors. J Biol Chem. 2017 04 07; 292(14):5748-5759.
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What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling. Eur J Immunol. 2016 11; 46(11):2507-2511.
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Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol. 2007 Dec; 27(24):8698-712.
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Bradykinin B2 receptor activates extracellular signal-regulated protein kinase in mIMCD-3 cells via epidermal growth factor receptor transactivation. J Pharmacol Exp Ther. 2003 Mar; 304(3):968-77.
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Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase. J Immunol. 1999 Dec 01; 163(11):5891-5.
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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J Biol Chem. 1998 Nov 13; 273(46):30630-7.
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G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. J Biol Chem. 1997 Dec 12; 272(50):31648-56.
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B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. J Biol Chem. 1996 Dec 13; 271(50):32306-14.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. Biochemistry. 1996 Oct 29; 35(43):13716-22.
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Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature. 1995 Aug 31; 376(6543):781-4.