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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
Immunity, Active
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
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PubMed
subject areas
Antineoplastic Agents
bcl-X Protein
Cell Line
Cell Survival
Humans
Leukemia
Lysine
Models, Molecular
Proteasome Endopeptidase Complex
Protein Binding
Protein Conformation
Proteolysis
Proto-Oncogene Proteins c-bcl-2
Small Molecule Libraries
Ubiquitination
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein
authors with profiles
Shaun K. Olsen