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    • Report from the 17th Conference on Retroviruses and Opportunistic Infections. CCR5 antagonists--out with the old, in with the new?
    • Budhoo, David
    • Dipette, Donald
    • Receptor, Fibroblast Growth Factor, Type 3
    • Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.

View in: PubMed

subject areas
  • Antineoplastic Agents
  • bcl-X Protein
  • Cell Line
  • Cell Survival
  • Humans
  • Leukemia
  • Lysine
  • Models, Molecular
  • Proteasome Endopeptidase Complex
  • Protein Binding
  • Protein Conformation
  • Proteolysis
  • Proto-Oncogene Proteins c-bcl-2
  • Small Molecule Libraries
  • Ubiquitination
  • Ubiquitin-Conjugating Enzymes
  • Ubiquitin-Protein Ligases
  • Von Hippel-Lindau Tumor Suppressor Protein

authors with profiles
  • Shaun K. Olsen