CDC2 Protein Kinase

"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.

Descriptor ID	D016203
MeSH Number(s)	D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
Concept/Terms	CDC2 Protein Kinase CDC2 Protein Kinase Protein Kinase, CDC2 Cdk1 Protein Kinase Protein Kinase, Cdk1 cdk1 Kinase cdc2+ Protein Cyclin-Dependent Kinase 1 Cyclin Dependent Kinase 1 p34cdc2 Protein p34cdc2 Protein Protein p34cdc2 p34cdc2, Protein Histone Kinase p34(cdc2)

Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.500.250]
Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.984.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
CDC2 Protein Kinase [D12.644.360.250.067.249]
Maturation-Promoting Factor [D12.644.360.250.580]
CDC2 Protein Kinase [D12.644.360.250.580.500]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
CDC2 Protein Kinase [D12.776.167.200.067.249]
Maturation-Promoting Factor [D12.776.167.200.580]
CDC2 Protein Kinase [D12.776.167.200.580.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
CDC2 Protein Kinase [D12.776.476.250.067.249]
Maturation-Promoting Factor [D12.776.476.250.580]
CDC2 Protein Kinase [D12.776.476.250.580.500]
Phosphoproteins [D12.776.744]
CDC2 Protein Kinase [D12.776.744.360]

Below are MeSH descriptors whose meaning is related to "CDC2 Protein Kinase".

Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1993 and 1994 and 1995 and 2000 and 2005 and 2011 and 2013 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	1	1
1994	1	0	1
1995	1	0	1
2000	0	1	1
2005	0	1	1
2011	1	0	1
2013	1	0	1
2014	0	1	1

Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.

Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19.

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Warfel NA, Dolloff NG, Dicker DT, Malysz J, El-Deiry WS. CDK1 stabilizes HIF-1a via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle. 2013 Dec 01; 12(23):3689-701.

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Mayes PA, Dolloff NG, Daniel CJ, Liu JJ, Hart LS, Kuribayashi K, Allen JE, Jee DI, Dorsey JF, Liu YY, Dicker DT, Brown JM, Furth EE, Klein PS, Sears RC, El-Deiry WS. Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3ß and CDK1. Cancer Res. 2011 Aug 01; 71(15):5265-75.

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Lin DI, Aggarwal P, Diehl JA. Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8079-84.

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McInnes C, Fischer PM. Strategies for the design of potent and selective kinase inhibitors. Curr Pharm Des. 2005; 11(14):1845-63.

View in: PubMed
Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene. 2000 Apr 20; 19(17):2165-70.

View in: PubMed
Eblen ST, Fautsch MP, Burnette RJ, Snyder M, Leof EB. Dissociation of p34cdc2 complex formation from phosphorylation and histone H1 kinase activity. Cancer Res. 1995 May 01; 55(9):1994-2000.

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Eblen ST, Fautsch MP, Burnette RJ, Joshi P, Leof EB. Cell cycle-dependent inhibition of p34cdc2 synthesis by transforming growth factor beta 1 in cycling epithelial cells. Cell Growth Differ. 1994 Feb; 5(2):109-16.

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Reddy KB, Howe PH. Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest. J Cell Physiol. 1993 Jul; 156(1):48-55.

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Longstreet M, Miller B, Howe PH. Loss of transforming growth factor beta 1 (TGF-beta 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells. Oncogene. 1992 Aug; 7(8):1549-56.

View in: PubMed

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