"Genes, bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
| Descriptor ID |
D019254
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.150
|
| Concept/Terms |
Genes, bcl-2- Genes, bcl-2
- Genes, bcl 2
- bcl-2 Genes
- Gene, bcl-2
- bcl 2 Genes
- bcl-2 Gene
c-bcl-2 Genes- c-bcl-2 Genes
- Gene, c-bcl-2
- Genes, c-bcl-2
- c bcl 2 Genes
- c-bcl-2 Gene
- c-bcl-2 Proto-Oncogenes
- Proto-Oncogene, c-bcl-2
- Proto-Oncogenes, c-bcl-2
- c bcl 2 Proto Oncogenes
- c-bcl-2 Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, bcl-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, bcl-2".
This graph shows the total number of publications written about "Genes, bcl-2" by people in this website by year, and whether "Genes, bcl-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
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Below are the most recent publications written about "Genes, bcl-2" by people in Profiles.
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Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study. J Virol. 2011 Jan; 85(1):397-409.
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Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal. 2010 Jun 15; 12(12):1339-53.
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The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells. Cancer Res. 2008 Apr 01; 68(7):2358-65.
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Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. Blood. 2007 Apr 01; 109(7):3069-75.
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Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol Sci. 2004 Mar; 78(1):116-24.
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Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization. J Biol Chem. 2004 Mar 19; 279(12):10855-63.
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The origin of anti-nuclear antibodies in bcl-2 transgenic mice. Int Immunol. 2000 Mar; 12(3):353-64.
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EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene. 2000 Feb 10; 19(6):745-53.
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Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4.