"Focal Adhesion Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
| Descriptor ID |
D051417
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.500 D12.776.744.493
|
| Concept/Terms |
Focal Adhesion Kinase 1- Focal Adhesion Kinase 1
- Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
- Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
- p125FAK Protein
- Protein Tyrosine Kinase 2
- Endogenous Substrate pp120
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 1".
This graph shows the total number of publications written about "Focal Adhesion Kinase 1" by people in this website by year, and whether "Focal Adhesion Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Focal Adhesion Kinase 1" by people in Profiles.
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Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. J Neurosci. 2020 10 28; 40(44):8463-8477.
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun. 2020 05 15; 11(1):2416.
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Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model. PLoS One. 2015; 10(10):e0140273.
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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13.
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The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol Biol Cell. 2014 Mar; 25(6):739-52.
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ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms. Can J Physiol Pharmacol. 2010 Aug; 88(8):850-4.
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B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21; 284(34):22865-77.
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Protein phosphatase-2A maintains focal adhesion complexes in keratinocytes and the loss of this regulation in squamous cell carcinomas. Clin Exp Metastasis. 2004; 21(4):371-9.
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PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol. 2003 Jul 21; 162(2):281-91.
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FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration. J Cell Biol. 2003 Apr 28; 161(2):393-402.