Serine C-Palmitoyltransferase
"Serine C-Palmitoyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL COENZYME A to 3-dehydro-D-sphinganine. The enzyme consists of two different subunits.
| Descriptor ID |
D051102
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| MeSH Number(s) |
D08.811.913.050.668
|
| Concept/Terms |
Serine C-Palmitoyltransferase- Serine C-Palmitoyltransferase
- C-Palmitoyltransferase, Serine
- Serine C Palmitoyltransferase
- Serine Palmitoyltransferase
- Palmitoyltransferase, Serine
- Palmitoyl-CoA-L-Serine C-Palmitoyltransferase (Decarboxylating)
- Palmitoyl-Coenzyme A-L-Serine C-Palmitoyltransferase (Decarboxylating)
Long Chain Base Biosynthesis Protein 2- Long Chain Base Biosynthesis Protein 2
- Serine-Palmitoyl-CoA Transferase 2
- Serine Palmitoyl CoA Transferase 2
- Transferase 2, Serine-Palmitoyl-CoA
- Serine Palmitoyltransferase 2
- Palmitoyltransferase 2, Serine
- Serine Palmitoyltransferase, Long Chain Base Subunit 2
|
Below are MeSH descriptors whose meaning is more general than "Serine C-Palmitoyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Serine C-Palmitoyltransferase".
This graph shows the total number of publications written about "Serine C-Palmitoyltransferase" by people in this website by year, and whether "Serine C-Palmitoyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Serine C-Palmitoyltransferase" by people in Profiles.
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Ceramide and Sphingosine Regulation of Myelinogenesis: Targeting Serine Palmitoyltransferase Using microRNA in Multiple Sclerosis. Int J Mol Sci. 2019 Oct 11; 20(20).
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Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res. 2018 11; 59(11):2126-2139.
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Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae. J Lipid Res. 2018 01; 59(1):162-170.
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Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. J Am Acad Dermatol. 2017 Aug; 77(2):268-273.e6.
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Sphingosine Toxicity in EAE and MS: Evidence for Ceramide Generation via Serine-Palmitoyltransferase Activation. Neurochem Res. 2017 Oct; 42(10):2755-2768.
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Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):12962-7.
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Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. J Biol Chem. 2013 May 10; 288(19):13397-409.
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
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Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. Neurochem Res. 2012 Jun; 37(6):1154-69.
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Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. J Cell Physiol. 2010 Mar; 222(3):546-55.