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    • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. 2014 Sep 18; 124(12):1915-25.

View in: PubMed

subject areas
  • Adamantane
  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Caspase 3
  • Cell Line, Tumor
  • Cell Proliferation
  • Down-Regulation
  • Enzyme Inhibitors
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, Knockout
  • Mice, SCID
  • Multiple Myeloma
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Phosphotransferases (Alcohol Group Acceptor)
  • Proteasome Endopeptidase Complex
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-myc
  • Pyridines
  • RNA, Messenger
  • RNA, Neoplasm
  • RNA, Small Interfering
  • Xenograft Model Antitumor Assays

authors with profiles
  • Elizabeth Garrett Garrett-Mayer
  • Besim Ogretmen
  • Robert K. Stuart