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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. 2014 Sep 18; 124(12):1915-25.
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PubMed
subject areas
Adamantane
Animals
Antineoplastic Agents
Apoptosis
Caspase 3
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Enzyme Inhibitors
Humans
Mice
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Multiple Myeloma
Myeloid Cell Leukemia Sequence 1 Protein
Phosphotransferases (Alcohol Group Acceptor)
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myc
Pyridines
RNA, Messenger
RNA, Neoplasm
RNA, Small Interfering
Xenograft Model Antitumor Assays
authors with profiles
Elizabeth Garrett Garrett-Mayer
Besim Ogretmen
Robert K. Stuart