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    • Metabolic stress modulates Alzheimer's ?-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons.
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Metabolic stress modulates Alzheimer's ?-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons.

Metabolic stress modulates Alzheimer's ?-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons. Cell Metab. 2013 May 07; 17(5):685-94.

View in: PubMed

subject areas
  • Acetylation
  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Animals
  • Aspartic Acid Endopeptidases
  • Down-Regulation
  • Mice
  • Mice, Inbred C57BL
  • Neurons
  • Nitric Oxide Synthase Type III
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • PPAR gamma
  • Promoter Regions, Genetic
  • Rats
  • Sirtuin 1
  • Stress, Physiological
  • Transcription Factors
  • Transcription, Genetic
  • Up-Regulation

authors with profiles
  • Narayan R. Bhat