Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24.

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subject areas

Adenocarcinoma
Animals
Anticarcinogenic Agents
Apoptosis
Carcinogenesis
Cell Line, Tumor
Cell Proliferation
Chalcone
Cullin Proteins
Disease Models, Animal
Dose-Response Relationship, Drug
Genetic Predisposition to Disease
Humans
Male
Mice, Inbred C57BL
Mice, Transgenic
Molecular Docking Simulation
NEDD8 Protein
Phenotype
Prostatic Neoplasms
Proteasome Endopeptidase Complex
Protein Binding
Protein Processing, Post-Translational
Proteolysis
Retinoblastoma Protein
S-Phase Kinase-Associated Proteins
Time Factors
Transfection
Ubiquitination
Ubiquitin-Conjugating Enzymes
Ubiquitins

authors with profiles

Michael B. Lilly