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Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942.

View in: PubMed

subject areas
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols
  • Cell Proliferation
  • Cyclin D
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Enzyme Activation
  • HCT116 Cells
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Mechanistic Target of Rapamycin Complex 2
  • Mice
  • Molecular Targeted Therapy
  • Multiprotein Complexes
  • Neoplasms
  • Phosphorylation
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-akt
  • Retinoblastoma Protein
  • RNA Interference
  • Signal Transduction
  • Time Factors
  • TOR Serine-Threonine Kinases
  • Transfection

authors with profiles
  • Wenjian Gan