"Transducin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
| Descriptor ID |
D015293
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.800 D12.644.360.360.940 D12.776.157.325.332.940 D12.776.476.375.940 D12.776.543.325.800
|
| Concept/Terms |
Transducin- Transducin
- Transducin G-Protein (Gt)
- Gt, Transducin G-Protein
- G-Protein Gt, Transducin
- Gt, Transducin G Protein
- Transducin G-Protein Gt
- G-Protein, Inhibitory Gt
- G Protein, Inhibitory Gt
- Gt G-Protein, Inhibitory
- Inhibitory Gt G-Protein
gamma-Transducin- gamma-Transducin
- gamma Transducin
- Transducin, gamma Subunit
- gamma Subunit Transducin
beta-Transducin- beta-Transducin
- beta Transducin
- Transducin, beta Subunit
- beta Subunit Transducin
alpha-Transducin- alpha-Transducin
- alpha Transducin
- Transducin, alpha Subunit
- alpha Subunit Transducin
|
Below are MeSH descriptors whose meaning is more general than "Transducin".
Below are MeSH descriptors whose meaning is more specific than "Transducin".
This graph shows the total number of publications written about "Transducin" by people in this website by year, and whether "Transducin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 2 | 3 |
| 2005 | 1 | 2 | 3 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 1 | 3 |
| 2011 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Transducin" by people in Profiles.
-
Probing human red cone opsin activity with retinal analogues. J Nat Prod. 2011 Mar 25; 74(3):391-4.
-
Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci. 2010 Feb 17; 30(7):2496-503.
-
In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol. 2010; 652:85-94.
-
Assays for inverse agonists in the visual system. Methods Enzymol. 2010; 485:213-24.
-
Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304.
-
Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. J Biol Chem. 2008 Nov 07; 283(45):31197-207.
-
11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry. 2008 Jul 15; 47(28):7567-71.
-
Differences in the pharmacological activation of visual opsins. Vis Neurosci. 2006 Nov-Dec; 23(6):899-908.
-
Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1473-9.
-
A dark and constitutively active mutant of the tiger salamander UV pigment. Biochemistry. 2005 Jan 18; 44(2):799-804.