Low Density Lipoprotein Receptor-Related Protein-6
"Low Density Lipoprotein Receptor-Related Protein-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An LDL-receptor related protein that combines with cell surface FRIZZLED RECEPTORS to form WNT PROTEIN-binding receptors. The protein plays an important role in the WNT SIGNALING PATHWAY during EMBRYONIC DEVELOPMENT and in regulation of vascular cell proliferation.
| Descriptor ID |
D060488
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| MeSH Number(s) |
D12.776.526.600 D12.776.543.750.710.450.500.600 D12.776.543.750.850.781
|
| Concept/Terms |
Low Density Lipoprotein Receptor-Related Protein-6- Low Density Lipoprotein Receptor-Related Protein-6
- Low Density Lipoprotein Receptor Related Protein 6
- Low Density Lipoprotein Receptor-Related Protein 6
- Lipoprotein Receptor-Related Protein 6
- Lipoprotein Receptor Related Protein 6
|
Below are MeSH descriptors whose meaning is more general than "Low Density Lipoprotein Receptor-Related Protein-6".
Below are MeSH descriptors whose meaning is more specific than "Low Density Lipoprotein Receptor-Related Protein-6".
This graph shows the total number of publications written about "Low Density Lipoprotein Receptor-Related Protein-6" by people in this website by year, and whether "Low Density Lipoprotein Receptor-Related Protein-6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Low Density Lipoprotein Receptor-Related Protein-6" by people in Profiles.
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GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development. Adv Cancer Res. 2016; 129:165-90.
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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res. 2013 Nov 15; 19(22):6242-51.
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Kallistatin antagonizes Wnt/?-catenin signaling and cancer cell motility via binding to low-density lipoprotein receptor-related protein 6. Mol Cell Biochem. 2013 Jul; 379(1-2):295-301.
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Disabled-2 (Dab2) inhibits Wnt/?-catenin signalling by binding LRP6 and promoting its internalization through clathrin. EMBO J. 2012 May 16; 31(10):2336-49.
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Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. J Biol Chem. 2012 Feb 03; 287(6):3823-32.