"Ceramidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.
| Descriptor ID |
D055572
|
| MeSH Number(s) |
D08.811.277.087.250
|
| Concept/Terms |
Ceramidases- Ceramidases
- Ceramidase
- N-Acylsphingosine Amidohydrolase
- Amidohydrolase, N-Acylsphingosine
- N Acylsphingosine Amidohydrolase
- Acylsphingosine Deacylase
- Deacylase, Acylsphingosine
|
Below are MeSH descriptors whose meaning is more general than "Ceramidases".
Below are MeSH descriptors whose meaning is more specific than "Ceramidases".
This graph shows the total number of publications written about "Ceramidases" by people in this website by year, and whether "Ceramidases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2010 | 2 | 1 | 3 |
| 2011 | 2 | 0 | 2 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ceramidases" by people in Profiles.
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Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases. PLoS One. 2022; 17(9):e0271540.
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Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies. Photochem Photobiol Sci. 2020 Sep 09; 19(9):1145-1151.
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Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850.
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The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Curr Alzheimer Res. 2015; 12(9):847-59.
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Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29; 6(299):rs14.
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
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Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov; 10(11):2052-61.
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712.
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem. 2010 Mar 12; 285(11):7964-76.