"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
|
| MeSH Number(s) |
D08.811.520.224.125.425
|
| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 1 | 3 |
| 1995 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. Cancer Gene Ther. 2022 07; 29(7):940-950.
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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677.
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A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. PLoS One. 2015; 10(5):e0127246.
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Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino Acids. 2014 Mar; 46(3):543-52.
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Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013 Feb 22; 15:e3.
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Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochem J. 2009 Jul 29; 422(1):101-9.
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Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008 Apr 01; 68(7):2214-22.
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Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. J Natl Cancer Inst. 2006 Oct 18; 98(20):1494-500.
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PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology. 2003 Jun; 28(6):1026-30.
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Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother Pharmacol. 1995; 36(1):69-74.