Adenosylmethionine Decarboxylase
"Adenosylmethionine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.
| Descriptor ID |
D012437
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| MeSH Number(s) |
D08.811.520.224.125.050
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| Concept/Terms |
Adenosylmethionine Decarboxylase- Adenosylmethionine Decarboxylase
- Decarboxylase, Adenosylmethionine
- S-Adenosylmethionine Decarboxylase
- Decarboxylase, S-Adenosylmethionine
- S Adenosylmethionine Decarboxylase
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Below are MeSH descriptors whose meaning is more general than "Adenosylmethionine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Adenosylmethionine Decarboxylase".
This graph shows the total number of publications written about "Adenosylmethionine Decarboxylase" by people in this website by year, and whether "Adenosylmethionine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Adenosylmethionine Decarboxylase" by people in Profiles.
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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677.
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Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. J Biol Chem. 2011 Dec 16; 286(50):43301-12.
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The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug; 384(8):1195-201.
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S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem. 1995 May 12; 38(10):1770-7.
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Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4- methylsulfonio-2-cyclopentene (AdoMac). Biochem Pharmacol. 1995 Apr 18; 49(8):1125-33.
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Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli. Bioorg Med Chem. 1993 Nov; 1(5):349-60.
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S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase. J Med Chem. 1992 Aug 21; 35(17):3196-201.
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Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 1989 Oct 17; 28(21):8446-53.