Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 1 | 3 |
| 1998 | 2 | 0 | 2 |
| 1999 | 3 | 1 | 4 |
| 2000 | 3 | 0 | 3 |
| 2001 | 1 | 1 | 2 |
| 2002 | 3 | 2 | 5 |
| 2003 | 3 | 2 | 5 |
| 2004 | 7 | 7 | 14 |
| 2005 | 5 | 2 | 7 |
| 2006 | 3 | 3 | 6 |
| 2007 | 1 | 5 | 6 |
| 2008 | 3 | 1 | 4 |
| 2009 | 4 | 0 | 4 |
| 2010 | 4 | 3 | 7 |
| 2011 | 2 | 3 | 5 |
| 2012 | 3 | 4 | 7 |
| 2013 | 9 | 5 | 14 |
| 2014 | 13 | 3 | 16 |
| 2015 | 8 | 5 | 13 |
| 2016 | 6 | 3 | 9 |
| 2017 | 7 | 2 | 9 |
| 2018 | 10 | 2 | 12 |
| 2019 | 5 | 4 | 9 |
| 2020 | 5 | 4 | 9 |
| 2021 | 2 | 4 | 6 |
| 2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Stroke Severity among Men and Women Acute Ischemic Stroke Patients in the Telestroke Network. Cerebrovasc Dis Extra. 2022; 12(2):93-101.
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Retrospective analysis of comorbidities in stroke patients with a history of obstructive sleep apnea treated with thrombolytic therapy. J Vasc Nurs. 2022 06; 40(2):74-85.
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Acute Ischemic Stroke and Heart Failure: Stroke Risk Factors Associated with Exclusion from Thrombolytic Therapy. Clin Appl Thromb Hemost. 2022 Jan-Dec; 28:10760296221116347.
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Risk factors and ambulatory outcome in ischemic stroke patients with pre-stroke depression. J Vasc Nurs. 2021 Dec; 39(4):91-99.
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Trends in mechanical thrombectomy and decompressive hemicraniectomy for stroke: A multicenter study. Neuroradiol J. 2022 Apr; 35(2):170-176.
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Clinical Risk Factors Associated with Ambulatory Outcome in Acute Ischemic Stroke Patient Smokers Treated with Thrombolytic Therapy. Am J Med Sci. 2021 10; 362(4):363-374.
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Telestroke Consultation in the Emergency Medical Services Unit: A Novel Approach to Improve Thrombolysis Times. J Stroke Cerebrovasc Dis. 2021 May; 30(5):105710.
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POSITIVE: Perfusion imaging selection of ischemic stroke patients for endovascular therapy. J Neurointerv Surg. 2022 Feb; 14(2):126-132.
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Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data. J Neurointerv Surg. 2021 Dec; 13(12):1073-1080.
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The multiarm optimization of stroke thrombolysis phase 3 acute stroke randomized clinical trial: Rationale and methods. Int J Stroke. 2021 10; 16(7):873-880.