Clusterin

"Clusterin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.

Descriptor ID	D051152
MeSH Number(s)	D12.776.395.207 D12.776.580.215
Concept/Terms	Clusterin Clusterin SGP-2 Protein SGP 2 Protein Apolipoprotein J Complement Lysis Inhibitor Complement-Associated Protein SP-40,40 Complement Associated Protein SP 40,40 SP-40,40, Complement-Associated Protein Sulfated Glycoprotein 2 Sulfated Glycoprotein-2 Ionizing Radiation-Induced Protein-8 Ionizing Radiation Induced Protein 8 Radiation-Induced Protein-8, Ionizing XIP8 Protein X-Ray-Inducible Protein 8 X Ray Inducible Protein 8 Testosterone-Repressed Prostate Message-2 Protein Testosterone Repressed Prostate Message 2 Protein ApoJ Protein TRPM-2 Protein TRPM 2 Protein MAC393 Antigen SP 40,40 Protein

Below are MeSH descriptors whose meaning is more general than "Clusterin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Clusterin [D12.776.395.207]
Molecular Chaperones [D12.776.580]
Clusterin [D12.776.580.215]

Below are MeSH descriptors whose meaning is related to "Clusterin".

Below are MeSH descriptors whose meaning is more specific than "Clusterin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Clusterin" by people in this website by year, and whether "Clusterin" was a major or minor topic of these publications.

Bar chart showing 12 publications over 7 distinct years, with a maximum of 3 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	2	2
1999	0	1	1
2001	0	1	1
2004	0	3	3
2010	2	0	2
2015	1	0	1

Below are the most recent publications written about "Clusterin" by people in Profiles.

Ebbert MTW, Boehme KL, Wadsworth ME, Staley LA, Mukherjee S, Crane PK, Ridge PG, Kauwe JSK. Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement. 2016 Feb; 12(2):121-129.

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Hoofnagle AN, Wu M, Gosmanova AK, Becker JO, Wijsman EM, Brunzell JD, Kahn SE, Knopp RH, Lyons TJ, Heinecke JW. Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2528-34.

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Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec; 67(12):1473-84.

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Erranz B, Miquel JF, Argraves WS, Barth JL, Pimentel F, Marzolo MP. Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids. J Lipid Res. 2004 Dec; 45(12):2185-98.

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Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Howe PH, Piedrafita FJ. The retinoid antagonist MX781 induces clusterin expression in prostate cancer cells via heat shock factor-1 and activator protein-1 transcription factors. Cancer Res. 2004 Aug 15; 64(16):5905-12.

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Imai M, Hwang HY, Norris JS, Tomlinson S. The effect of dexamethasone on human mucin 1 expression and antibody-dependent complement sensitivity in a prostate cancer cell line in vitro and in vivo. Immunology. 2004 Mar; 111(3):291-7.

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Lakshman R, Tsutsumi M, Ghosh P, Takase S, Anni H, Nikolaeva O, Israel Y, Anton RF, Lesch OM, Helender A, Eriksson G, Jeppson JO, Marmillot P, Rao MN. Alcohol biomarkers: clinical significance and biochemical basis. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):67S-70S.

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Jin G, Howe PH. Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos. Eur J Biochem. 1999 Jul; 263(2):534-42.

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Jin G, Howe PH. Regulation of clusterin gene expression by transforming growth factor beta. J Biol Chem. 1997 Oct 17; 272(42):26620-6.

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Hammad SM, Ranganathan S, Loukinova E, Twal WO, Argraves WS. Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem. 1997 Jul 25; 272(30):18644-9.

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