"Sequestosome-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
| Descriptor ID |
D000071456
|
| MeSH Number(s) |
D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422
|
| Concept/Terms |
Sequestosome-1 Protein- Sequestosome-1 Protein
- Sequestosome 1 Protein
- Ubiquitin-Binding Protein p62
- Ubiquitin Binding Protein p62
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
- EBI3-Associated Protein of 60 KDa
- EBI3 Associated Protein of 60 KDa
- EBIAP Protein
|
Below are MeSH descriptors whose meaning is more general than "Sequestosome-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Sequestosome-1 Protein".
This graph shows the total number of publications written about "Sequestosome-1 Protein" by people in this website by year, and whether "Sequestosome-1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sequestosome-1 Protein" by people in Profiles.
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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circ Res. 2020 07 31; 127(4):502-518.
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Proteasome inhibition suppress microgravity elevated RANK signaling during osteoclast differentiation. Cytokine. 2020 01; 125:154821.
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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun. 2017 06 07; 8:15750.
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p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. PLoS One. 2017; 12(1):e0169291.
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The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem Cell Res. 2015 Sep; 15(2):312-21.
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Altered autophagy in the mice with a deficiency of saposin A and saposin B. Autophagy. 2013 Jul; 9(7):1115-6.
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Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone. Endocrinology. 2011 Nov; 152(11):4180-9.
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Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease. J Clin Invest. 2007 Jan; 117(1):133-42.
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Etiologic factors in Paget's disease of bone. Cell Mol Life Sci. 2006 Feb; 63(4):391-8.
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Etiology of Paget's disease and osteoclast abnormalities. J Cell Biochem. 2004 Nov 01; 93(4):688-96.