A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

Descriptor ID	D000071456
MeSH Number(s)	D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422
Concept/Terms	Sequestosome-1 Protein Sequestosome-1 Protein Sequestosome 1 Protein Ubiquitin-Binding Protein p62 Ubiquitin Binding Protein p62 Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda EBI3-Associated Protein of 60 KDa EBI3 Associated Protein of 60 KDa EBIAP Protein

Below are MeSH descriptors whose meaning is more general than "Sequestosome-1 Protein".

Below are MeSH descriptors whose meaning is related to "Sequestosome-1 Protein".

Below are MeSH descriptors whose meaning is more specific than "Sequestosome-1 Protein".