Homeobox Protein Nkx-2.5

"Homeobox Protein Nkx-2.5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A homeobox-containing transcription factor that functions in heart development. Mutations in the NKX2-5 gene are associated with ATRIAL SEPTAL DEFECTS and TETRALOGY OF FALLOT.

Descriptor ID	D000072576
MeSH Number(s)	D12.776.260.400.234 D12.776.930.324
Concept/Terms	Homeobox Protein Nkx-2.5 Homeobox Protein Nkx-2.5 Homeobox Protein Nkx 2.5 Nkx-2.5, Homeobox Protein NK2 Homeobox 5 Protein Homeobox Transcription Factor Csx-Nkx2-5 Homeobox Transcription Factor Csx Nkx2 5 Homeobox Protein Csx-Nkx2.5 Csx-Nkx2.5, Homeobox Protein Homeobox Protein Csx Nkx2.5 Cardiac-Specific Homeobox Protein Cardiac Specific Homeobox Protein Homeobox Protein, Cardiac-Specific Transcription Factor Nkx-2.5 Nkx-2.5, Transcription Factor Transcription Factor Nkx 2.5

Below are MeSH descriptors whose meaning is more general than "Homeobox Protein Nkx-2.5".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Homeodomain Proteins [D12.776.260.400]
Homeobox Protein Nkx-2.5 [D12.776.260.400.234]
Transcription Factors [D12.776.930]
Homeobox Protein Nkx-2.5 [D12.776.930.324]

Below are MeSH descriptors whose meaning is related to "Homeobox Protein Nkx-2.5".

Below are MeSH descriptors whose meaning is more specific than "Homeobox Protein Nkx-2.5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Homeobox Protein Nkx-2.5" by people in this website by year, and whether "Homeobox Protein Nkx-2.5" was a major or minor topic of these publications.

Bar chart showing 20 publications over 16 distinct years, with a maximum of 4 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1999	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	1	1
2005	0	2	2
2006	0	1	1
2007	0	1	1
2009	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	1	1
2013	0	1	1
2014	0	4	4
2015	0	1	1
2019	1	0	1

Below are the most recent publications written about "Homeobox Protein Nkx-2.5" by people in Profiles.

Horton AJ, Brooker J, Streitfeld WS, Flessa ME, Pillai B, Simpson R, Clark CD, Gooz MB, Sutton KK, Foley AC, Lee KH. Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. Sci Rep. 2019 02 11; 9(1):1738.

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Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR. Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Nucleic Acids Res. 2016 05 05; 44(8):3610-7.

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Cambier L, Plate M, Sucov HM, Pashmforoush M. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug; 141(15):2959-71.

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Ashraf H, Pradhan L, Chang EI, Terada R, Ryan NJ, Briggs LE, Chowdhury R, Zárate MA, Sugi Y, Nam HJ, Benson DW, Anderson RH, Kasahara H. A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Circ Cardiovasc Genet. 2014 Aug; 7(4):423-433.

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Rivers ER, Horton AJ, Hawk AF, Favre EG, Senf KM, Nietert PJ, Chang EY, Foley AC, Robinson CJ, Lee KH. Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia. Hypertens Pregnancy. 2014 Nov; 33(4):412-26.

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Perera JL, Johnson NM, Judge DP, Crosson JE. Novel and highly lethal NKX2.5 missense mutation in a family with sudden death and ventricular arrhythmia. Pediatr Cardiol. 2014 Oct; 35(7):1206-12.

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Targoff KL, Colombo S, George V, Schell T, Kim SH, Solnica-Krezel L, Yelon D. Nkx genes are essential for maintenance of ventricular identity. Development. 2013 Oct; 140(20):4203-13.

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Clark CD, Zhang B, Lee B, Evans SI, Lassar AB, Lee KH. Evolutionary conservation of Nkx2.5 autoregulation in the second heart field. Dev Biol. 2013 Feb 01; 374(1):198-209.

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Hahurij ND, Kolditz DP, Bökenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Blom NA. Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Pediatr Res. 2011 Jul; 70(1):37-43.

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Barth JL, Clark CD, Fresco VM, Knoll EP, Lee B, Argraves WS, Lee KH. Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn. 2010 Jul; 239(7):2024-33.

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