"Tristetraprolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA.
| Descriptor ID |
D051816
|
| MeSH Number(s) |
D12.776.260.790 D12.776.460.762 D12.776.930.960
|
| Concept/Terms |
Tristetraprolin- Tristetraprolin
- Tristetraprolin Protein
- G0-G1 Switch Regulatory Protein 24
- G0 G1 Switch Regulatory Protein 24
- Zinc Finger Protein 36
|
Below are MeSH descriptors whose meaning is more general than "Tristetraprolin".
Below are MeSH descriptors whose meaning is more specific than "Tristetraprolin".
This graph shows the total number of publications written about "Tristetraprolin" by people in this website by year, and whether "Tristetraprolin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tristetraprolin" by people in Profiles.
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Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice. Redox Biol. 2020 10; 37:101609.
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Tristetraprolin Is Required for Alveolar Bone Homeostasis. J Dent Res. 2018 07; 97(8):946-953.
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Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem. 2011 Jul 08; 286(27):23717-24.
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The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology. 2009 May; 136(5):1669-79.
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Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction. J Clin Invest. 1997 Sep 01; 100(5):986-95.
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A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 1996 May; 4(5):445-54.