Deubiquitinating Enzyme CYLD
"Deubiquitinating Enzyme CYLD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
| Descriptor ID |
D000074749
|
| MeSH Number(s) |
D08.811.037.375 D12.776.624.776.482
|
| Concept/Terms |
Deubiquitinating Enzyme CYLD- Deubiquitinating Enzyme CYLD
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
- CYLD Protein
|
Below are MeSH descriptors whose meaning is more general than "Deubiquitinating Enzyme CYLD".
Below are MeSH descriptors whose meaning is more specific than "Deubiquitinating Enzyme CYLD".
This graph shows the total number of publications written about "Deubiquitinating Enzyme CYLD" by people in this website by year, and whether "Deubiquitinating Enzyme CYLD" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Deubiquitinating Enzyme CYLD" by people in Profiles.
-
CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes. J Mol Cell Cardiol. 2020 08; 145:59-73.
-
Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. J Mol Cell Cardiol. 2015 Jul; 84:143-53.
-
CYLD-mediated signaling and diseases. Curr Drug Targets. 2015; 16(4):284-94.
-
A pro-inflammatory role of deubiquitinating enzyme cylindromatosis (CYLD) in vascular smooth muscle cells. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):78-83.
-
Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion. Chin Med J (Engl). 2009 Nov 05; 122(21):2603-7.
-
An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy. Biochem Biophys Res Commun. 2009 Dec 11; 390(2):307-12.