1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
| Descriptor ID |
D019307
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| MeSH Number(s) |
D02.886.590.700.545 D03.383.606.527 D03.633.100.531.400
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
Below are MeSH descriptors whose meaning is more specific than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
This graph shows the total number of publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in this website by year, and whether "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in Profiles.
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Lichtman SN, Wang J, Lemasters JJ. Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. J Leukoc Biol. 1998 Sep; 64(3):368-72.
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Shiota T, Bernanke DH, Parent AD, Hasui K. Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage. Stroke. 1996 Oct; 27(10):1889-95.
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Khan WA, Blobe GC, Richards AL, Hannun YA. Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35.
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Mitchell MD, LaMarche S, Adamson S, Coulam C, Silver RM, Edwin SS. Regulation of intrauterine prostaglandin biosynthesis: interactions between protein kinase C and interleukin 1 beta. Prostaglandins Leukot Essent Fatty Acids. 1994 Mar; 50(3):137-40.
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Kalivas PW. Blockade of neurotensin-induced motor activity by inhibition of protein kinase. Psychopharmacology (Berl). 1994 Feb; 114(1):175-80.
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Bhat NR, Hauser KF, Kindy MS. Cell proliferation and protooncogene induction in oligodendroglial progenitors. J Neurosci Res. 1992 Jul; 32(3):340-9.
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Khan W, el Touny S, Hannun YA. Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS Lett. 1991 Nov 04; 292(1-2):98-102.
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Geisel J, Cook JA, Coffee KA, Wise WC, Halushka PV. Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. Biochim Biophys Acta. 1991 Aug 20; 1085(1):15-20.
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Hannun YA, Merrill AH, Bell RM. Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28.
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Spivak JL, Hogans BB, Stuart RK. Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells. J Clin Invest. 1989 Jan; 83(1):100-7.