"Neurofilament Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
| Descriptor ID |
D016900
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| MeSH Number(s) |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".
Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".
This graph shows the total number of publications written about "Neurofilament Proteins" by people in this website by year, and whether "Neurofilament Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neurofilament Proteins" by people in Profiles.
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Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation. Microbiol Spectr. 2022 02 23; 10(1):e0197521.
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Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3. Folia Histochem Cytobiol. 2012 Jul 05; 50(2):312-8.
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Estrogen treatment of spinal cord injury attenuates calpain activation and apoptosis. J Neurosci Res. 2006 Oct; 84(5):1064-75.
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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol. 2006 Mar; 59(3):478-89.
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A role for calpain in optic neuritis. Ann N Y Acad Sci. 2005 Aug; 1053:48-54.
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Characterization of the bovine neurofilament NF-M protein and cDNA sequence, and identification of in vitro and in vivo calpain cleavage sites. Biochem Biophys Res Commun. 2004 Dec 10; 325(2):619-25.
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Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat. J Neurosci. 2003 Mar 15; 23(6):2265-73.
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Relationship between the induction of RAGE cell-surface antigen and the expression of amyloid binding sites. J Mol Neurosci. 2003; 20(3):223-32.
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E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats. Brain Res. 2000 Jun 09; 867(1-2):80-9.
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Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res. 2000 Jan 10; 852(2):326-34.