Fragile X Mental Retardation Protein

"Fragile X Mental Retardation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A RNA-binding protein that is found predominately in the CYTOPLASM. It helps regulate GENETIC TRANSLATION in NEURONS and is absent or under-expressed in FRAGILE X SYNDROME.

Descriptor ID	D051860
MeSH Number(s)	D12.776.157.725.061 D12.776.631.299 D12.776.664.962.124
Concept/Terms	Fragile X Mental Retardation Protein Fragile X Mental Retardation Protein FMRP Protein Fragile X Mental Retardation-1 Protein Fragile X Mental Retardation 1 Protein

Below are MeSH descriptors whose meaning is more general than "Fragile X Mental Retardation Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
Fragile X Mental Retardation Protein [D12.776.157.725.061]
Nerve Tissue Proteins [D12.776.631]
Fragile X Mental Retardation Protein [D12.776.631.299]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
Fragile X Mental Retardation Protein [D12.776.664.962.124]

Below are MeSH descriptors whose meaning is related to "Fragile X Mental Retardation Protein".

Below are MeSH descriptors whose meaning is more specific than "Fragile X Mental Retardation Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fragile X Mental Retardation Protein" by people in this website by year, and whether "Fragile X Mental Retardation Protein" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2012 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2008	1	0	1
2010	1	0	1
2011	0	1	1
2012	0	2	2
2013	2	0	2
2014	1	0	1
2016	1	0	1
2018	1	0	1
2020	1	0	1

Below are the most recent publications written about "Fragile X Mental Retardation Protein" by people in Profiles.

Majumder M, Johnson RH, Palanisamy V. Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer. Crit Rev Biochem Mol Biol. 2020 10; 55(5):409-424.

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Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcohol Clin Exp Res. 2018 Apr; 42(4):706-717.

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Spencer KB, Mulholland PJ, Chandler LJ. FMRP Mediates Chronic Ethanol-Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus. Alcohol Clin Exp Res. 2016 06; 40(6):1251-61.

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Smith LN, Jedynak JP, Fontenot MR, Hale CF, Dietz KC, Taniguchi M, Thomas FS, Zirlin BC, Birnbaum SG, Huber KM, Thomas MJ, Cowan CW. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron. 2014 May 07; 82(3):645-58.

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Smith LN, Cowan CW. Striking a balance in fragile X. Nat Med. 2013 Nov; 19(11):1370-1.

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Zang T, Maksimova MA, Cowan CW, Bassel-Duby R, Olson EN, Huber KM. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol Cell Neurosci. 2013 Sep; 56:39-49.

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Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012 Dec 21; 151(7):1581-94.

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Jung KM, Sepers M, Henstridge CM, Lassalle O, Neuhofer D, Martin H, Ginger M, Frick A, DiPatrizio NV, Mackie K, Katona I, Piomelli D, Manzoni OJ. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun. 2012; 3:1080.

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Burruss DM, Wood TC, Espinoza L, Dwivedi A, Holden KR. Severe Hunter syndrome (mucopolysaccharidosis II) phenotype secondary to large deletion in the X chromosome encompassing IDS, FMR1, and AFF2 (FMR2). J Child Neurol. 2012 Jun; 27(6):786-90.

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Pfeiffer BE, Zang T, Wilkerson JR, Taniguchi M, Maksimova MA, Smith LN, Cowan CW, Huber KM. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 2010 Apr 29; 66(2):191-7.

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