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Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2.

Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. J Mol Cell Cardiol. 2015 Jul; 84:143-53.

View in: PubMed

subject areas
  • Animals
  • Cardiomegaly
  • Cysteine Endopeptidases
  • Deubiquitinating Enzyme CYLD
  • Down-Regulation
  • Extracellular Signal-Regulated MAP Kinases
  • Gene Knockdown Techniques
  • Gene Silencing
  • Heart Failure
  • Humans
  • Male
  • Mice, Knockout
  • Models, Biological
  • Myocardium
  • Myocytes, Cardiac
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • p38 Mitogen-Activated Protein Kinases
  • Pressure
  • Proto-Oncogene Proteins c-myc
  • Rats
  • Signal Transduction
  • Survival Analysis
  • Transcription Factor AP-1
  • Tumor Suppressor Proteins
  • Ubiquitin Thiolesterase
  • Ultrasonography
  • Up-Regulation
  • Ventricular Remodeling

authors with profiles
  • Taixing Cui